The DDIT3 Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to CHOP, CHOP10, DDIT3, and GADD153. This antibody recognizes Human antigen. The DDIT3 Antibody (Center) has been validated for the following applications: ELISA, Flow Cytometry, and Western Blot.
Description
This gene encodes a member of the CCAAT/enhancer-binding
protein (C/EBP) family of transcription factors. The protein
functions as a dominant-negative inhibitor by forming heterodimers
with other C/EBP members, such as C/EBP and LAP (liver activator
protein), and preventing their DNA binding activity. The protein is
implicated in adipogenesis and erythropoiesis, is activated by
endoplasmic reticulum stress, and promotes apoptosis. Fusion of
this gene and FUS on chromosome 16 or EWSR1 on chromosome 22
induced by translocation generates chimeric proteins in myxoid
liposarcomas or Ewing sarcoma. Multiple alternatively spliced
transcript variants encoding two isoforms with different length
have been identified